产品货号：
Z24390
中文名称：
PREX2抗体
英文名称：
Anti-PREX2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PREX2 Antibody |
| 指标别名 | PREX2;DEPDC2;Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein;P-Rex2;PtdIns(3,4,5)s-dependent Rac exchanger 2;DEP domain-containing protein 2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,Direct ELISA |
| 基因名称 | PREX2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human PREX2 recombinant protein (Position:D582-Q1094). |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family,which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins.Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain,two disheveled,EGL-10,and pleckstrin homology (DEP) domains,two PDZ domains,and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms.This protein facilitates the exchange of GDP for GTP on Rac1,allowing the GTP-bound Rac1 to activate downstream effectors.Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity,thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway.Conversely,the PTEN gene product has also been shown to inhibit the GEF activity of this protein.This gene plays a role in insulin-signaling pathways,and either mutations or overexpression of this gene have been observed in some cancers. |
| Uniprot ID | Q70Z35 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 |
| 蛋白名全称 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Direct ELISA 1:100～1000 |
| Gene ID | 80243 |
相关搜索：PREX2抗体，PREX2多抗，Anti-PREX2 Antibody